CALL FOR PAPERS Mitochondrial Metabolism Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart
نویسندگان
چکیده
T. S. Lancaster, S. J. Jefferson, J. Craig Hunter, Veronica Lopez, J. E. Van Eyk, E. G. Lakatta, and D. H. Korzick Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania; IGDP in Physiology, The Pennsylvania State University, University Park, Pennsylvania; Department of Medicine, Johns Hopkins University, Baltimore, Maryland; and Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
منابع مشابه
Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart.
The incidence of myocardial infarction rises sharply at menopause, implicating a potential role for estrogen (E(2)) loss in age-related increases in ischemic injury. We aimed to identify quantitative changes to the cardiac mitochondrial proteome of aging females, based on the hypothesis that E(2) deficiency exacerbates age-dependent disruptions in mitochondrial proteins. Mitochondria isolated f...
متن کاملCALL FOR PAPERS Mitochondrial Function/Dysfunction in Health and Disease Local delivery of a PKCε-activating peptide limits ischemia reperfusion injury in the aged female rat heart
Lancaster TS, Jefferson SJ, Korzick DH. Local delivery of a PKCε-activating peptide limits ischemia reperfusion injury in the aged female rat heart. Am J Physiol Regul Integr Comp Physiol 301: R1242–R1249, 2011. First published August 31, 2011; doi:10.1152/ajpregu.00851.2010.—Reduced efficacy of cardioprotective interventions in the aged female heart, including estrogen replacement, highlights ...
متن کاملLocal delivery of a PKCε-activating peptide limits ischemia reperfusion injury in the aged female rat heart.
Reduced efficacy of cardioprotective interventions in the aged female heart, including estrogen replacement, highlights the need for alternative therapeutics to reduce myocardial ischemia-reperfusion (I/R) injury in postmenopausal women. Here, we sought to determine the efficacy of protein kinase-Cε (PKCε)-mediated cardioprotection in the aged, estradiol-deficient rat heart. Infarct size and fu...
متن کاملThe effect of eight weeks of aerobic training with Propolis on some mitochondrial biogenesis markers in cardiac tissue of ovariectomized diabetic rats
Background and aims: Postmenopausal is associated with heart and metabolic disorders. Although the beneficial role of physical activity and antioxidants in human health has been reported; However, the interactive effects of Aerobic training (AT) and Propolis (Pr) on mitochondrial biogenesis in cardiac tissue is not well understood. The aim of this study was to investigate the effect of eight we...
متن کاملCALL FOR PAPERS Sex Diferences in Renal and Cardiovascular Function: Physiology and Pathophysiology Estrogen deficiency decreases ischemic tolerance in the aged rat heart: roles of PKC , PKC , Akt, and GSK3
Hunter JC, Kostyak JC, Novotny JL, Simpson AM, Korzick DH. Estrogen deficiency decreases ischemic tolerance in the aged rat heart: roles of PKC , PKC , Akt, and GSK3 . Am J Physiol Regul Integr Comp Physiol 292: R800–R809, 2007. First published September 28, 2006; doi:10.1152/ajpregu.00374.2006.—The mechanisms underlying the age-dependent reversal of female cardioprotection are poorly understoo...
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